
Dr. Kalaiyarasu, S.
Senior Scientist
Ph.D.,Veterinary Immunology
Email : kalaiyarasu[dot]s[at]icar[dot]gov[dot]in
Awards and Recognitions
- Recipient of Sir. F.M. Burnett Memorial Award-2007 by the Indian Society for Veterinary Immunology and Biotechnology (ISVIB), Chennai.
- Recipient of ICAR, Junior Research Fellowship for M.V.Sc., in Veterinary Microbiology.
Publication
- Moorthy D., Mishra N., Kalaiyarasu S., Jhade S.K., Singh V.P., (2019). Evaluation of currently available bovine viral diarrhoea virus (BVDV) and HoBi-like pestivirus (HoBiPeV) specific diagnostic tests in detection of highly divergent HoBiPeVs in cattle.Journal of Virological methods. 272:113707.
- Moorthy D., Mishra N., Kalaiyarasu S., Jhade S.K., Singh VP., (2019). HoBi-like Pestivirus (HoBiPeV), An Emerging Bovine pestivirusdoes not use non-classical endocytic mechanisms for entry into ovine cells. Journal of Immunology and Immunopathology, 21 (2): 82-87.
- Sudhakar SB, Mishra N, Kalaiyarasu S, Jhade SK, Hemadri D, Sood R, Bal GC,Nayak MK, Pradhan SK, Singh VP. Lumpy skin disease (LSD) outbreaks in cattle inOdisha state, India in August 2019: Epidemiological features and molecularstudies. TransboundEmerg Dis. 2020 Apr 18.
- Kalaiyarasu S, Mishra N, Rajukumar K, Behera SP, Jhade SK and Singh VP (2019) Development and evaluation of real-time RT-PCR using ear hair for specific detection of sheep persistently infected with border disease virus (BDV). Journal of Virological Methods, 269, 55-63. doi: 10.1016/j.jviromet.2019.04.003.
- Gautam S, Mishra N, Kalaiyarasu S, Jhade SK, Sood R. Molecular characterization of Bovine Leukaemia Virus (BLV) strains reveals existence of genotype 6 in cattle in India with evidence of a new subgenotype. Transbound. Emerg. Dis. 2018;00:1–11. https://doi.org/ 10.1111/tbed.12979.
- Senthilkumar D, Rajukumar K, Kumar M, Kalaiyarasu S, Shrivastava D, Katare M, Kulkarni DD, Singh VP. (2018) Porcine reproductive and respiratory syndrome virus induces concurrent elevation of High Mobility Group Box-1 protein and pro-inflammatory cytokines in experimentally infected piglets. Cytokine. pii: S1043-4666(18)30246-1. doi: 10.1016/j.cyto.2018.06.002.
- Senthilkumar D, Rajukumar K, Sen A, Kumar M, Shrivastava D, Kalaiyarasu S, Gautam S, Singh F, Kulkarni DD, Singh VP. (2018) Pathogenic characterization of porcine reproductive and respiratory syndrome virus of Indian origin in experimentally infected piglets. Transbound Emerg Dis. doi: 10.1111/tbed.12893.
- Mishra N, Behera SP, Kalaiyarasu S, Nema RK, Pandey P and Rajukumar K. (2018). Complete genome sequence analyses of an indian cattle strain of bovine viral diarrhoea virus 2 (BVDV-2). Indian Journal of Experimental Biology. 56. 322-326.
- Mishra, N., Kalaiyarasu, S., Mallinath, KC., Rajukumar, K., Rohit, K., Gautam, S., Venkatesha, MD., Byregowda, SM. (2018) Identification of bovine viral diarrhea virus type 2 in cattle bull semen from southern India and its genetic characterization. Current Science, 114 (3): 666-670.
- Bhat, S., Sood, R., Shukla, S., Khandia, R., Pateriya, A.K., Kumar, N., Singh, V.K., Kalaiyarasu, S., Kumar, M., Bhatia, S. (2018). A two dose immunization with an inactivated reassortant H5N2 virus protects chickens against lethal challenge with homologous 2.3.2.1 clade and heterologous 2.2 clade highly pathogenic avian influenza H5N1 viruses. Veterinary Microbiology 217; 149–157.
- Dash, S.K., Kumar, M., Kataria, J. M., Nagarajan, S., Tosh, C., Murugkar, H., Rajukumar, K., Kalaiyarasu, S., Senthil Kumar, D., Kulkarni, D.D. (2018). Induction profiles of mRNA of toll like receptors and cytokines in chickens pre-exposed to low pathogenic avian influenza H9N2 virus followed by challenge with highly pathogenic avian influenza H5N1 virus. Microbial Pathogenesis 117; 200–205.
- Singh V, Mishra N, Kalaiyarasu S, Khetan RK, Hemadri D, Singh RK, Rajukumar K, Chamuah J, Suresh KP, Patil SS, Singh VP (2017) First report on serological evidence of bovine viral diarrhea virus (BVDV) infection in farmed and free ranging mithuns (Bos frontalis), Trop Anim Health Prod., 49(6):1149-1156.
- Senthil Kumar, D., Rajukumar, K., Jeena, K., Kalaiyarasu, S., Kumar, M., Shrivastava, D., Bano, F.H., Kulkarni, D.D. and Singh, V.P. (2017). Pulmonary Alveolar Macrophages Reveal Higher Basal Cytokine mRNA Expression than Peripheral Blood Leucocytes in Healthy Piglets. Journal of Animal Research: v.7 n.4, p. 629-634.
- Kalaiyarasu, S., Kumar, M., Kumar, D. S., Bhatia, S., Dash, S. K., Bhat, S., Khetan, R. K. and Nagarajan, S. 2016. Highly pathogenic avian influenza H5N1 virus induced cytokine dysregulation with suppressed maturation of chicken monocyte derived dendritic cells.MicrobiolImmunol. 60(10): 687–693.
- Kalaiyarasu S, Mishra N, Khetan R.K, Singh V.P. (2016). Serological evidence of widespread West Nile virus and Japanese encephalitis virus infection in native domestic ducks (Anasplatyrhynchos var domesticus) in Kuttanad region, Kerala, India. Comparative Immunology, Microbiology and Infectious Diseases. 48, 61–68. doi:10.1016/j.cimid.2016.08.002.
- Kalaiyarasu S, Bhatia S, Mishra N, Sood R, Kumar M, Senthil Kumar D, Bhat S, Dass Prakash M (2016). Elevated level of pro inflammatory cytokine and chemokine expression in chicken bone marrow and monocyte derived dendritic cells following LPS induced maturation. Cytokine 23;85:140-147. doi: 10.1016/j.cyto.2016.06.022.
- Mishra N, Rajukumar K, Vilcek S, Kalaiyarasu S, Behera SP, Dubey P, Nema RK, Gavade VB, Dubey SC, Kulkarni DD. (2016) Identification and molecular characterization of border disease virus (BDV) from sheep in India. Comparative Immunology, Microbiology and Infectious Diseases. 44, 1–7.
- B R Das, M Kumar, H V Murugkar, S Nagarajan, D Senthil Kumar, S Kalaiyarasu, D D Kulkarni and C Tosh (2016). Experimental inoculation of a crow derived influenza A (H5N1) virus in chickens and its pathological and genetic characterization. Indian Journal of Animal Sciences 86 (3): 238–242.
- Y. T. Redda, G. Venkatesh, S. Kalaiyarasu, S. Bhatia, D. Senthil Kumar, S. Nagarajan, A. Pillai, S. Tripathi, D. D. Kulkarni & S. C. Dubey (2016): Expression and purification of recombinant H5HA1 protein of H5N1 avian influenza virus in E. coli and its application in indirect ELISA, Journal of Immunoassay and Immunochemistry, DOI: 10.1080/15321819.2015.1135160.
- Karikalan M, Rajukumar K, Mishra N, Kumar M, Kalaiyarasu S, Rajesh K, Gavade V, Behera SP and Dubey SC (2016) Distribution pattern of bovine viral diarrhoea virus type 1 genome in lymphoid tissues of experimentally infected sheep, Veterinary Research Communications. DOI: 10.1007/s11259-016-9654-9.
- Behera SP, Mishra N, Nema RK, Pandey PD, Kalaiyarasu S, Rajukumar K, Prakash A (2015) Expression of Bovine Viral Diarrhea Virus Envelope Glycoprotein E2 in Yeast Pichia pastoris and its Application to an ELISA for Detection of BVDV Neutralizing Antibodies in Cattle. J Immunoassay Immunochem. 36:639-54.
- Dubey P, Mishra N, Rajukumar K, Behera SP, Kalaiyarasu S, Nema RK, Prakash A (2015). Development of a RT-PCR ELISA for simultaneous detection of BVDV-1, BVDV-2 and BDV in ruminants and its evaluation on clinical samples. J Virol Methods. 213: 50-6.
- Behera SP, Mishra N, Nema RK, Pandey PD, Kalaiyarasu S, Rajukumar K, Prakash A (2015). Expression of Bovine Viral Diarrhea Virus Envelope Glycoprotein E2 in Yeast Pichia pastoris and its Application to an ELISA for Detection of BVDV Neutralizing Antibodies in Cattle. J Immunoassay Immunochem. 36(6):639-54.
- Behera P, Nagarajan S, Murugkar HV, Kalaiyarasu S, Prakash A, Gothalwal R, Dubey SC, Kulkarni DD, Tosh C (2015). siRNAs targeting PB2 and NP genes potentially inhibit replication of Highly Pathogenic H5N1 Avian Influenza Virus. J Biosci. 40(2):233-40.
- Kalaiyarasu S, Mishra N, Rajukumar K, Nema RK, Behera SP. (2015) Development and evaluation of a truncated recombinant NS3 antigen-based indirect ELISA for detection of pestivirus antibodies in sheep and goats. Journal of Immunoassay and Immunochemistry, 36(3):312-23. doi: 10.1080/15321819.2014.947433.
- Kalaiyarasu S., M. K. Saxena , R. S. Gupta (2013). Emerging of Multiple drug resistance in Salmonella Typhimurium serovars isolated from Indian Ganga river. Advances in Animal and Veterinary Sciences. 1 (1S): 1 – 3.
- Mishra, N,, Kalaiyarasu, S., Nagarajan, S., Rao, M. V., George, A., Sridevi, R., Behera, S. P., Dubey, S. C., McCracken, T. and Newman, S. H. 2012. Serological evidence of West Nile virus infection in wild migratory and resident water birds in Eastern and Northern India. Comp Immunol Microbiol Infect Dis. 2012 Aug 24. doi.org/10.1016/j.cimid.2012.08.002.
- Mishra N, Rajukumar K, Kalaiyarasu S, Behera SP, Nema RK, Dubey SC. (2011). Small interfering RNAs targeting viral structural envelope protein genes and the 5ʹ-UTR inhibit replication of bovine viral diarrhea virus in MDBK cells. Acta Virologica, 55(3): 279-282.
- S. P. Behera, N. Mishra, S. Vilcek, K. Rajukumar, R. K. Nema, A. Prakash, S. Kalaiyarasu, S. C. Dubey (2011).Genetic and antigenic characterization of bovine viral diarrhoea virus type 2 isolated from cattle in India. Comparative Immunology, Microbiology and Infectious Diseases 34, 189–196.
- N. Mishra, K. Rajukumar, S. Kalaiyarasu, S. C. Dubey (2011). Pestivirus infection, an emerging threat to ruminants in India: a review. Indian journal of Animal sciences 81(6):545-551.
Review Articles
- Karthik K, Muneeswaran NS, Manjunathachar HV, Gopi M, Elamurugan A, Kalaiyarasu S (2014). Bacteriophages: Effective alternative to anitbiotics. Adv. Anim. Vet. Sci. 2 (3s): 1-7.
Technical bulletin/manual
- N. Mishra, K. Rajukumar and S. Kalaiyarasu, S.C. Dubey (2011). Laboratory manual for diagnosis of Bovine Viral Diarrhoea (BVD).
Popular Articles - 09
Abstracts- 08
Project
- Diagnosis and surveillance of BVD/BD in ruminant population in India (As Co-Investigator, ongoing institute service project).
- ‘Surveillance and diagnostic preparedness for West Nile Virus infection in Migratory birds.’ (As Co-Investigator, ongoing institute service project).
- ‘Alterations in immunocompetent cells and cytokines in the pathogenesis of acute Bovine Viral Diarrhoea Virus infection in Sheep’. (As Co-Investigator, ongoing DST project).
- ‘Development of one-step Taqman real time RT-PCR for detection and genetic typing of ruminant pestiviruses’ (As Co-Investigator, IVRI funded project, completed).
Equal Opportunity for Persons with Disabilities
In accordance with the provisions of the Right of Persons with Disabilities Act, 2016 and Rules, the institute strives to provide opportunities and facilities to persons with disabilities to participate, perform and excel in their work on an equal basis in everyday life.